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Abstract

RECENT ADVANCES IN THE MANAGEMENT OF PARKINSON’S DISEASE

Jasleen Kaur*

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Abstract

Parkinson‟s disease (PD) is a neurodegenerative disorder more commonly found in elderly between the ages of 60-65. Rigidity, bradykinesia, tremors and postural instabilities are the characteristics of PD. The symptoms of PD can be classified into; motor symptoms (speech difficulties, dysphagia, dystonia, tremors etc.) and non-motor symptoms (cognitive impairment, anxiety, sleep disorders etc.).The etiology of PD is still unknown, however it is considered to be caused by a blend of various genetic and environmental factors. The hallmark of PD is the presence of alphasynuclein containing lewy bodies in the substantia nigra region of the brain. The main cause of PD is due to degeneration of dopaminergic neurons in the brain which can be due to various reasons like toxicity caused by specific proteins, mutations, exposure to toxins etc. The drug treatments only focus on symptomatic relief and temporal improvement is limited. Hence in order to achieve significant results on both motor and nonmotor symptoms multiple new approaches like ablative surgeries, gene editing, identification of therapeutic targets are being considered to enhance the management of PD.

Keywords: Parkinsonism, lewy bodies, ?-syn toxicity, familial PD, CRISPR, therapeutic targets.


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