Abstract

ANTIMICROBIAL ACTIVITY OF MANNICH BASES OF 1H-INDOLE- 2, 3-DIONE: A REVIEW

Shobhit Shrivastava* and Dharmendra Ahuja

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Abstract

Resistance in pathogenic microbes is natural problem and it always provoke the researcher to develop more clinically important chemical moiety. Various Mannich bases of aromatic and heterocyclic compounds for their potent diverse microbial broad-spectrum activities have been reported. Mannich bases are results of Mannich reactions, which involve a nucleophilic addition reaction in which a condensation of active hydrogen with amines and aldehyde take place. Due to structure versatility of the 1H-indole-2, 3-dione (isatin), it always attracts the researcher for the preparation of novel moiety with different substitution at position 5 and imine formation with condensation with 3-oxo group. In this brief review we focused on the Mannich bases of 1Hindole- 2, 3-dione with antibacterial and antifungal activity.

Keywords: 1H-indole-2, 3-dione, Mannich base, antimicrobial activity, Mannich reaction.