Abstract

REVIEW ON MICRONEEDLE DRUG DELIVERY SYSTEM

Shraddha Mahajan*, Sonam Choudhary, Devshree Gayakwad, Dr. Sweta Koka, Dr. Pravin Sharma and Dr. G. N. Darwhekar

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Abstract

In recent years, a transdermal drug delivery system which combines the technology of transdermal patches and hypodermic needles, have been the focus of research and development. Because traditional needles are hundreds of microns long, they cause extremely little or no discomfort. The stratum corneum, the outermost layer of the skin, functions as a lipid barrier for molecules, restricting their pharmacological effectiveness. As a result, only a few molecules make it to the action site. Microneedles are a brand-new delivery method. These delivery techniques help to improve medicine delivery through this channel while reducing the problems that standard formulations cause. Because the usage of micro-needles bypasses the stratum corneum barrier, it has gotten a lot of interest. The pharmaceutical technique necessitates breaking the epidermal layer, which has led to research into producing a micron-sized needle that allows the medicine to reach the systemic circulation without being obstructed. The mechanics and applications of microneedles were explained in this review. Microneedles can be made in a variety of shapes and sizes, including solid, dissolving, hydrogel, coated, and hollow. The kind and material of the microneedle usually determine the fabrication procedure. This technique has a broader use and significance in a variety of sectors, including cancer, vaccine administration, insulin delivery, and cosmetics. Many microneedle products have been offered on the market in recent years. Although much work and research is required to overcome the obstacles, it may also increase the performance of microneedles.

Keywords: Microneedle, solid microneedle, coated microneedle, dissolved microneedle.