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Abstract

A REVIEW ON GRDDS RECENT ADVANCES IN DRUG DELIVERY SYSTEMS AND ITS APPLICATION

Swadesh Kumar Vishwakarma*, Jai Narayan Mishra and Dhaneshwar Kumar Vishwakarma

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Abstract

One such shown technique is the drug delivery system with gastroretentive characteristics, aiming at locally or systemically releasing particular drugs. In the pharmaceutical business, much emphasis has been given to the development of controlled oral release and site-specific medicines to achieve better therapeutic benefits. Drug absorption is a very variable process in the gastrointestinal system and extending gastric dose form retention extends the drug absorption duration. In the upper section of a gastrointestinal system, this technique is especially beneficial for medication usage with a restricted absorption window. This review also provides an outline of the merits, demerits and assessment factors. There are many advantages to the development of the Gastro retention system, such as enhancing drug bioavailability, increasing the solubility of less soluble drugs at high pH, controlling the therapeutic rate thereby reducing the fluctuations incidence and thus reducing the consumption for half-life. This review article focuses on various essential methods for delivering gastroretentive medicines (floating, bioadhesive, high-density, swelling, raft forming, and magnetic systems) in different dosing forms.

Keywords: GRDDS, evaluation parameters, non-floating system, floating system, applications.


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