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Abstract

FORMULATION AND EVALUATION OF ACYCLOVIR LOADED MICROSOMAL GEL

Altaf Hussain Bin Sami*, Dr. Jagdish Chandra Rathi, Mr. Rahul Sharma

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Abstract

Microsomes are novel drug delivery system that promotes the importantly ease and convenience of administration, deliverance of accurate dose as well as to prolong residence time of drug in contact with skin that problems. Acyclovir is white crystalline, tasteless, odorless, substance was sparingly soluble in water. λmax was determined in Phosphate buffer (pH 7.4) solvent at 251.3 nm. Standard calibration curve was prepared using concentration range 04-20μg/ml. Five different formulations were prepared all the sodium alginate solutions were prepared by dissolving the respective amounts in distilled water. Dried microcapsules were subjected for Evaluation were found yield between 83.54 to 94.22 %, mean particle size between 568.65 to 751.82 μm and % encapsulation between 80. 21 to 97.01% and swelling Index between 3.04to3.64, shape was spherical with slightly elongated tips found in some microspheres. On the basis of various parameter of evaluation of microsomal gel formulations, pH of all formulations were adjusted about 6.63, viscosity at 5 rpm was maximum at 58767 cps, % drug content between 98.69 to 100.35% and Spreadability maximum 12.69 gm.cm/sec. All formulation (P-1 to P-5) with a blank formulation (P-0 only pure drug) and a marketed formulation were subjected for diffusion study with cellophane membrane and egg membrane. Cumulative amount of drug released Q (μg/cm2) at different time intervals and steady state flux (Jss, μg/cm2.hr) were obtained. Also permeability coefficient (Kp) and enhancement ratio (ER) are calculated and found P-5 has highest enhancement ratio (ER) 2.29 and P-4 has 2.02. Also it was observed that the flux and permeability of Acyclovir goes on increasing as the concentration of Nerolidol increases. Accelerated Stability studies for 30 days was performed with optimized Microsomes batch P- 5 for physical examination observed no visible change, % Drug content after stability and before stability were 98.01 and 100.33 respectively.

Keywords: Acyclovir, Microsomal Gel, Microsome, Evaluation.


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