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Abstract

ROLE OF PROPHYLACTIC TRANEXAMIC ACID IN REDUCING POSTPARTUM HEMORRHAGE IN FEMALES UNDERGOING CESAREAN SECTION

Huma Achakzai, Arifa Inayat, Rehana Kamal*, Roona Khan, Farida Kakar and Prof. Dr. Aisha Siddiqa

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Abstract

Aim: To compare the frequency of postpartum hemorrhage among patients undergoing C-section with prophylactic tranexamic acid verses IV oxytocin. Study Design: Randomized controlled trial. Place and Duration of Study: Department of Obstetrics & Gynecology, Sandeman Provincial hospital Quetta from 1-3-2020 to 31-8-2020. Methodology: Three hundred and ninety eight females (198 in each group) undergoing lower segment cesarean section of 18-40 years of age were selected. Patients with previous history of anticoagulation therapy and adherent placenta like placenta accreta and previa were excluded. In group A TXA was given 1 gm before delivery of the fetus at the time of anesthesia while in Group B 10 units of I/V Oxytocin was given to all females before delivery at the time of anesthesia. Using cord traction method placenta was delivered in each female. Using operational definition PPH was measured by subtracting the weight of wet gauze from weight of dry gauze. Results: Group A women showed average age 28.19±4.46 years with average gestational age was 39.63±1.15 weeks and group B showed average age was 29.19±3.49 years and gestational age was 39.83±1.46 weeks. The group A showed average similarity of 3.40±0.98 and group B indicated 3.37±1.01. There was postpartum hemorrhage in 51 (25.76%) patients in Group A (tranexamic acid) while in Group B (IV oxytocin), it was seen in 88 (44.44%) patients with p- value of 0.0001. Conclusion: There is less frequency of postpartum hemorrhage among patients undergoing C-section with prophylactic tranexamic acid as compared to IV oxytocin.

Keywords: Frequency, Post-partum hemorrhage, Cesarean section, Prophylactic tranexamic acid.


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