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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
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Abstract

CLINICAL AND RADIOGRAPHIC COMPARISON OF 0.05% ZOLEDRONATE GEL (ZOMETA) ®AND 1% ALENDRONATE GEL (FOSAMAX) ® AS A LOCAL DRUG DELIVERY IN THE TREATMENT OF CHRONIC PERIODONTITIS- A SPLIT MOUTH STUDY

*Dr. Rameshwari B., Dr. Suchetha Aghanashini, Dr. Sapna Nadiger, Dr. Darshan B. Mundinamane, Dr. Apoorva S. M., Dr. Divya Bhat, Dr. Shwetha Baliga

.

Abstract

Aim: The purpose of the study was to compare clinically and radiographically the efficacy of 0.05% zoledronate gel and 1% alendronate gel as a local drug delivery in the treatment of chronic periodontitis. Materials & Method: 45 surgical sites were selected in 15 patients and treated with SRP alone, SRP + 1% Alendronate gel and SRP + 0.05% zoledronate gel. Plaque index(PI), Gingival index(GI), Sulcus bleeding index(SBI), Probing Pocket Depth (PPD) Clinical Attachment Level Depth of defect (DOD) were recorded at baseline, 3months and 6 months postoperatively. The bone-fill was evaluated at baseline, 3 months and 6 months with the help of a PSP plate system. Result: Significant PI and GI reduction, probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain and significant bone fill (BF) was observed in both Alendronate and Zoledronate treated sites. Conclusion: Both Alendronate and Zoledronate was effective in the treatment of intrabony defects with Zoledronate showing superior results.

Keywords: Bisphosphonate, Intrabony defects, Local drug delivery.


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