Abstract

CLINICAL AND RADIOGRAPHIC COMPARISON OF 0.05% ZOLEDRONATE GEL (ZOMETA) ®AND 1% ALENDRONATE GEL (FOSAMAX) ® AS A LOCAL DRUG DELIVERY IN THE TREATMENT OF CHRONIC PERIODONTITIS- A SPLIT MOUTH STUDY

*Dr. Rameshwari B., Dr. Suchetha Aghanashini, Dr. Sapna Nadiger, Dr. Darshan B. Mundinamane, Dr. Apoorva S. M., Dr. Divya Bhat, Dr. Shwetha Baliga

.

Abstract

Aim: The purpose of the study was to compare clinically and radiographically the efficacy of 0.05% zoledronate gel and 1% alendronate gel as a local drug delivery in the treatment of chronic periodontitis. Materials & Method: 45 surgical sites were selected in 15 patients and treated with SRP alone, SRP + 1% Alendronate gel and SRP + 0.05% zoledronate gel. Plaque index(PI), Gingival index(GI), Sulcus bleeding index(SBI), Probing Pocket Depth (PPD) Clinical Attachment Level Depth of defect (DOD) were recorded at baseline, 3months and 6 months postoperatively. The bone-fill was evaluated at baseline, 3 months and 6 months with the help of a PSP plate system. Result: Significant PI and GI reduction, probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain and significant bone fill (BF) was observed in both Alendronate and Zoledronate treated sites. Conclusion: Both Alendronate and Zoledronate was effective in the treatment of intrabony defects with Zoledronate showing superior results.

Keywords: Bisphosphonate, Intrabony defects, Local drug delivery.