WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION DEVELOPMENT AND PHARMACOLOGICAL EVALUATION OF HERBAL HYDROGELS FOR DERMAL WOUND HEALING

G. Siva Krishna*, K. M. Manjanna, Madhavi BLR and M. Sabareesh

.

Abstract

In the present study two medicinal plants Centella asiatica (Umbelliferae) and Aloe vera (Liliaceae) reported to have significant wound healing potential were selected to be formulated as herbal hydrogels and were investigated for their wound healing activity. The main objective of the study was design and development of novel herbal hydrogels for wound repair. The dried finely ground herb centella asiatica was extracted in ethanol by successive solvent extraction process and the ethanolic extract was screened for its phytochemical constituents and gave positive report for the presence of Carbohydrates, Flavonoids, Alkaloids and Gums. Aloe vera leaves are collected and further processed to obtain Aloe vera gel. A Preformulation study was performed prior to the development of herbal hydrogels formulation. The Preformulation studies revealed that the herbal drug and selected polymers were compatible. Optimized formula was designed and further three formulations were prepared namely HHF-1, HHF-2 and HHF-3 respectively with polyvinyl pyrolidone K-30 and glutaraldehyde as cross linking agent. In-vitro characterization like PH, Viscosity, Water absorption capacity, Skin irritation test was done for all the three formulations. From the three formulations HHF-2 formulation is having acceptable PH, excellent Viscosity -41991 Cps at 70% torque. Fair Water absorption capacity, possess antimicrobial activity against both Staphylococcus aureus and E.coli microorganisms as compared to standard and control, non-skin irritant and good Wound Healer.

Keywords: HHF-Herbal hydrogel formulation, CPS-centipoises, FT-IR-Fourier transform infra Red spectrophotometer, PVP-Polyvinyl pyrolidone, CMC-Carboxy methyl Cellulose, RPM-Rotations per minute.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More