Abstract

SYNTHESIS AND PHYSICO-CHEMICAL CHARACTERIZATION OF NOVEL OXAZOLINES

Lincy Joseph* and Mathew George

.

Abstract

The aim of present work is to synthesize novel oxazoline compounds and its characterization. The title compounds synthesized with the use of catalyst Pyridinium Hydrobromide PerBromide. Synthesis accomplished in two steps. Aaromatic aldehydes and Pyridinium Hydrobromide PerBromide added in l water and mixed well with constant stirring. The resultant solution poured to dimethyl amine or diethyl amine stirred well and added ethyl acetate. Solution stirred well for 6 hrs. at room temperature. The resultant mixture is washed with 0.5 M acq. sodium thiosulfate solution. And then successively washed with saline. Remove the solvent by evaporation. Collect the product and recrystallize from alcohol. All resultant compounds are characterized by IR, NMR and CHN analysis. Physicochemical characters also profiled. CHN analysis of all compounds done and results are incorporated.

Keywords: Oxazolines, Aromatic aldehydes, Pyridinium Hydrobromide Per Bromide.