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Abstract

AN EXPERIMENTAL EVALUATION OF THE ULCER PROTECTIVE ACTION OF BALADI MANDURA

*Dr. Salini V. S., Dr. RR. Geethesh, Dr. Ravindra Angadi, Dr. Ashok Kumar B.N., Dr. Sushmitha V.S.

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Abstract

Background: According to the international statistics, more than 50% of the world’s population is suffering with gastric irritation due to various causative factors. ‘Ayurveda’- the science of life, promising a better and efficacious remedy with different formulations. Mandura kalpana is one such group of medicines with Mandura being the key ingredient. Baladi mandura is one among the Mandura Kalpanas mentioned in Rasakamadhenu indicated in Amlapitta and Parinamashoola. Aims and objectives: To evaluate the ulcer protective action of Baladi MandAura by Shay’s method of pyloric ligation induced acid secretion and ulcer formation in Wistar strain albino rats. Methodology: The drugs were administered to the respective groups for 8 days by oral route. Ranitidine was taken as the standard drug for inducing ulcers. On 9th and 10th day after administering drugs to the respective groups, fasting and pyloric ligation performed respectively. The gastric juice collected for biochemical evaluation and stomach was cut opened for calculating ulcer index. The results were expressed as Mean ± SEM. Results: The trail group showed a non-significant reduction in volume of gastric juice, free acidity, total carbohydrate and ulcer index. Non- significant increase was seen in pH, protein and significant increase in total acidity. Experimentally the trial group showed a significant reduction of ulcer formation by comparing with standard group. Conclusion: The increase in pH of gastric juice indicates the capacity of Baladi Mandura in neutralizing the gastric contents and the reduction in ulcer index showed the ulcer preventive action of Baladi Mandura.

Keywords: Ulcer index, Gastric juice, Protein, Mandura bhasma, Peptic ulcer diseases.


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