Abstract

A COMPREHENSIVE REVIEW ON NANOPARTICLE BASED TOPICAL OPHTHALMIC FORMULATIONS

Suchita Gokhale* and Dr. Vikas Jain

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Abstract

Ocular diseases in the anterior and posterior segment diseases. Because of complicated structure of anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional non-invasive and invasive treatments, such as eye drops, injections and implants, the current treatments either suffer from low bioavailability or severe adverse ocular effects. Newer emerging nanoscience and nanotechnology are important in the development of novel strategies for ocular disease therapy. Several active molecules have been designed as nanocarriers to overcome ocular barriers which is responsible for only 1-5% of drug to reach the ocular tissues. Nanocarrier drug delivery system will interact with specific ocular tissues. In this review, we elaborated on the recent attempts of nanotechnology-based systems for imaging and treating ocular diseases, such as corneal diseases, glaucoma, retina diseases, and choroid diseases. Although additional work remains, the progress described herein may pave the way to new, highly effective and important ocular nanomedicines. The review includes in situ ophthalmic gelling systems and ophthalmic solution which the prominent delivery systems. This review emphasis on improvement ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery systems for ophthalmic administration.

Keywords: Nanoparticles, Gels, Hydrogels, In situ gel, Polymers, Gelling mechanism.