Abstract

ASIATIC ACID: A PENTACYCLIC TRITERPENOID OF THERAPEUTIC POTENTIAL

Suvarna Bhadane* and Dr. Vikas Jain

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Abstract

In triterpenoids, Asiatic acid, a pentacyclic triterpenoid, has gained enormous attention due to its polypharmacological properties and therapeutic potential in numerous diseases. Asiatic acid possesses numerous pharmacological activities such as antioxidant and antiinflammatory and regulates apoptosis that attributes its therapeutic effects in numerous diseases. Asiatic acid showed potent antihypertensive, nootropic, neuroprotective, cardioprotective, antimicrobial, and antitumor activities in preclinical studies. In various in vitro and in vivo studies, asiatic acid is found to affect many enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signalling cascades. Asiatic acid showed favourable pharmacokinetics and was found bioavailable following oral or intraperitoneal administration. The present review targets to represent the available scientific reports on therapeutic potential and underlying pharmacological and molecular mechanisms of asiatic acid.

Keywords: Asiatic acid, Pentacyclic Triterpenoid, nanoformulations, nanocarriers, anticancer activity.