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Abstract

REVIEW ON LEIGH SYNDROME

Padmesh P. R.*, E. Sam Jeevakumar, Anusree V. S. and Gokul Krishna

Abstract

Leigh syndrome is defined as a severe neurological disorder characterized by a progressive loss of both mental and movement abilities. The symptoms will usually develop between the first three months to two years. Their common symptoms include problems with movement and balance, difficulty in talking, weak muscle tone and so on. Mainly it is seen in 1 in 40,000 newborns. Mutations of various genes cause Leigh syndrome which include mitochondrial DNA (mtDNA) mutations, and nuclear DNA (nDNA) mutations. Diagnosis of Leigh syndrome may be confirmed by using combined enzymatic and genetic analyses. There is no definitive treatment for cure and prevention for the affected patients, but have some tentative treatment which is administered to slow the progression of disease.

Keywords: Neurological disorder, infants, Mitochondrial DNA mutations, Nuclear DNA mutations.


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