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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF FLUCLOXACILLIN USING NATURAL POLYMER

Manoj Bisen*, Jagdish Chandra Rathi and Rahul Sharma

Abstract

Sustained release drug delivery system was meant to discharge the medication in a delayed rate to keep up plasma drug levels. The objective of the work was to design Sustained release matrix tablet of a flucloxacillin. The drug Flucloxacillin powder was examined found that Flucloxacillin was white crystalline odorless powder freely soluble in water, melting was 177 0C and Partition coefficient 0.29 ±0.06. Flucloxacillin solution was scanned in the U.V. range of 200-400 nm and max at 238 nm. The standard curves were prepared in 0.1 N HCl using max 238 nm.with correlation coefficient of 0.999 in the concentration range of 5-25g/ml. Physical compatibility study revealed there is no reaction between drug and polymer. Sustained release matrix tablet bathes were prepared by the dry granulation method. Firstly, granules were prepared and Micromeritic properties bulk density between 0.62 to 0.68, tapped density ranges 0.69 to 0.83, Compressibility Index between 7.24 to 25.3, Hausner’ratio ranges 1.08 to 1.34 and angle of repose ranges 24.38 to 33.12 were calculated. Sustained release matrix tablet bathes were evaluated under following parameters e.g. hardness from 5.3 to 7.3 kg/cm2, thickness from 2.4 to 2.7mm, diameter 9.1 for all, Weight variation from 1.75 to 6.21 %, content variation from 93.63 to 98.09 %, friability from 0.21 to1.85% and swelling index from 42 to68. On the basis these general evaluation of sustained release matrix tablet it was found, batch SR-2 shows good result. All batches were subjected for in-vitro Drug Release and obtained R2 values revealed that SR-2 possessed excellent drug release profile with R2 value 0.932. Drug Release profile of SR-2 the obtained data was expended for kinetic modeling and statistic representation and found that the batch SR-2 follows Zero Order kinetic model.

Keywords: Evaluation, Sustained Release, Matrix Tablet, Flucloxacillin, Natural Polymer.


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