Abstract

FORMULATION AND EVALUATION OF MULTIPLE EMULSION OF CLOTRIMAZOLE

Shiva Sahu*, Dr. Jagdish Chandra Rathi and Mr. Rahul Sharma

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Abstract

Multiple emulsions dosage formulation of clotrimazole which has enhanced release and bioavailability properties with less inter and intra- subject variability would be desirable. Thus, it was aimed to formulate and evaluate the multiple emulsion of clotrimazole. By the preformulation studies it is observed that clotrimazole is a white to pale yellow crystals having no odor. max was determined at 264 nm by scanning sample from 200-400nm and also calibration curve was obtained by absorbance of aliquots from 5-30 μg/ml. Partition coefficient was 1.797 obtained. Drug: Excipient Compatibility Studies at room temperature, 20C -80C and 450C -500C says it is stable. Stability also confirmed by FT-IR studies. All five Clotrimazole multiple emulsion formulations were odorless, washable, homogeneous, stable and free from grittiness and was evaluated under the various parameters, pH of all formulations were observed at 6.8 and viscosity between 40..23 to 76.38 centi poise and percentage of Drug content between 83.31 to 95.23%. In-vitro Drug Release of Clotrimazole multiple emulsion formulations were studied and found ME-1(87.61), ME-2(94.18), ME-3 (81.74), ME-4(83.74) and ME-5(78.62). Formulation ME-2 was found excellent on the basis of cumulative percentage of drug release profile. All five formulations were also tested for stability and found formulation ME-2 was stable. Optimized formulation (ME-2) drug release data were fitted into the zero order, first order, Higuchi and Peppas-Korsemeyer model of drug release kinetics.

Keywords: Multiple Emulsion, Clotrimazole, Evaluation.