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Abstract

FORMULATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVARY SYSTEM FOR CANDESARTAN

Sweta Rani*, Dr. Jagdish Chandra Rathi and Rahul Sharma

Abstract

Preformulation studies were carried out for physical characteristics revealed that drug was white color crystalline powder, bitter in taste, odorless. The solubility of the drug was found freely soluble in methanol and ethanol, sparingly soluble in chloroform and slightly soluble in water. UV spectrum was found absorption maxima (λmax) in scanning range of 200-400 nm was found to be at 263nm as per specification. The maximum solubility was determined in castor oil 143.63±1.51 mg/g and 122.83±2.56 mg/g of tween-80 as a surfactant phase and 178.26±2.05 mg/g of PEG-600 as a co-surfactant phase. The maximum % transmittance was found to be 87.7% at 3:2:1 (oil:surfactant:co-surfactant) ratio. Robustness to dilution was performed diluted with excess of water, standard phosphate buffer pH 6.8 and 0.1N HCl (500-900 ml) and was stored for 12 hours gives no precipitation or phase separation was found. Microscopic evaluation was performed morphology and structure of self emulsion using optical microscopy. The in-vitro performances of the formulation were visually assessed using the grading system. The emulsification time of SEDDS was determined as per procedure and maximum emulsification time was found in F2 formulation. The viscosities of the system were determined as such before and after dilution using Brookfield viscometer DV-E using spindle RV-6 at 100 rpm at 25±0.5OC. F-2 and F-4 were the final preparations on the basis of different evaluation parameters e.g. Assessment of self emulsification were grade A for both, lesser Emulsification time 11±1.52 and 15±2.51 seconds, also lesser Turbidity (NTU) 20 & 21cps, smaller droplets of size 173 ± 2.53 & 141.7 ± 1.02 and higher drug content 95.42 ± 1.13 & 94.52 ± 1.41. Hence, F-2 and F-4 formulations were selected for further evaluation for drug release. In-vitro drug Release of Candesartan SEDDS preparations were studied and found F-2 = 94.18 and GF-4 = 91.27, were excellent preparation on the basis of drug release profile.

Keywords: Evaluation, Self Emulsifying Drug Delivary System, SEDDS, Candesartan.


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