Abstract

SYNTHESIS, CHARACTERIZATION OF SOME NEWER ANTIBACTERIAL AND ANTHELMINTIC CARBAZOLE DERIVATIVES

Babita Kumari*, Deepanshu Sharma, Arpana Rana, Devender Pathak, Gyanendra Kumar Sharma and Sucheta

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Abstract

Carbazole is a very important entity that has a wide spectrum of therapeutic importance[1] Carbazole is a tricyclic compound which has total 12 carbon atoms in which two side rings are 6 carbon benzene ring which are fused with a five membered ring having one nitrogen atom.[2] Many potent medicinal compounds that have carbazole nucleus, are used as antidepressant[3], antibacterial[4], anticonvulsant[5], antidiabetic[6], antidiarrhoel[7], antifungal[8], antihypertensive[9], antiinflammatory [10], antioxidant[11], antitubercular[12], antitumour[13], prove the therapeutic importance of carbazole. Carbazole nucleus is also found in many naturally occurring medicinal compounds; For example, the carbazomycins are an unprecedented class of antibiotics with a carbazole framework. Carbazomycins A and B inhibit the growth of phytopathogenic fungi and have antibacterial and anti-yeast activities.[14] In this study, synthesis of some new derivatives of carbazole had been planned by incorporation of some benzaldehyde derivatives compounds at its 9th position further react with aniline that gave some new N-[(9H-Carbazol-9-yl)(substituted phenyl)methyl]benzenamine derivatives.

Keywords: Anthelmentic, Antibacterial, Open capillary method.