Abstract

PREPARATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NEW AZO LIGAND AND SOME OF IT'S METAL COMPLEXES

Asmaa. A. Al-hassani*, Abbas. H. Al-Khafagy and Abid Allah. M. Ali

Abstract

The present investigation describes the synthesis, characterization andantibacterial activity of the new azo ligand and its metal complexes.The new azo compound 1-[(3-Trifluromethylphenyl)azo]-2-naphthol(TFMAN) was prepared from coupling reaction oftrifluromethylphenyldiazonium chloride with 2-naphthol as couplingcomponent in a basic medium. The prepared ligand was characterizedby elemental and thermal analyses as well as FT-IR, UV-Vis and GCmassspectroscopic technique. Metal chelate complexes of this azoligand with metal ions Co(II), Ni(II), Cu(II) and Zn(II) were preparedby reacting (TFMAN) with the metal ions in a molar ratio of (1:2)(metal:ligand). All of the coordination compounds were identified by elemental analysis,flame atomic absorption, FT-IR, UV-Vis, magnetic susceptibility and conductivitymeasurements, in addition to thermal analyses and mass spectra for some of the chelatecomplexes. Based on the obtained results the geometry for the complexes was proposed. Theinvitro antibacterial activity of the synthesized compounds have been tested against grampositive and gram negative bacteria. The antibacterial activity assay results showed thatmetal complexes posses higher antibacterial activity compared to free ligand.

Keywords: Azo-naphthol, chelate complexes, FT-IR, UV-Vis and GC, mass spectrum, antibacterial activity.