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Abstract

ENHANCEMENT OF SOLUBILITY AND DEVELOPMENT OF FAST DISSOLVING ORAL FILM OF ATORVASTATIN

Shananaj Khan*, Shradha Shende, Dr. Navjot Singh

Abstract

The enhancement of dissolution rate and oral bioavailability of poorly soluble drugs remains one of the most challenging aspects of the drug development. Among the different methods of dissolution enhancement, Solid dispersion technology was found to be more successful with number of drugs. Solid dispersion of Atorvastatin with PEG 4000 was done by physical mixture method. Fast dissolving oral film containing Atorvastatin were prepared using solvent casting method. Total six formulations were prepared using varying amount of Sodium Starch glycolate and Cross-carmellose sodium. Percentage assay of different formulation was determined by U.V. vis Spectroscopy. The percentage assay of different formulation was in range of 95.23±0.65 to99.56±0.58%. The maximum percentage assay (99.56±0.58%) and less disintegration time were found in formulation F5 in fast dissolving oral film. The in vitro dissolution studies showed that Atorvastatin oral film formulation F5 showed maximum 89.98±0.25over a period of 15 min. Overall the results of the dissolution rate studies indicated greater dissolution rate of Atorvastatin from fast dissolving oral film.

Keywords: Atorvastatin, Solubility enhancement, fast dissolving oral film, evaluation.


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