Abstract

FLURBIPROFEN MICROSPHERES FOR THE TREATMENT OF ARTHRITIS

Reeta Shakya*, Suman Jain and Sunisha Kulkarni

.

Abstract

Oral modified-release multiple-unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Novel drug delivery systems have several advantages over conventional multi dose therapy. Recent trends indicate that micro particulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. Microspheres received much attention not only for prolonged release, but also for targeting of drugs. Micro particulate drug delivery systems provide tremendous opportunities for designing new controlled and delayed release oral formulations, thus extending the frontier of future pharmaceutical development. In future, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and effective drug delivery. The current aim of this research paper is to study various aspects of the micro particulate drug delivery system including method of formulation, evaluation and characterization.

Keywords: Microspheres, Controlled release, Novel Drug Delivery.