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Abstract

TOXICOLOGICAL EVALUATION OF BALADI MANDURA

Aswathy Nair*, Ravindra Angadi, Radhika Ranjan Geethesh, Dr. Ashok Kumar B.N.

Abstract

Baladi mandura is unique Herbo mineral formulation elucidated in Rasakamadhenu wherein mandura being the main ingredient. Usage of metals and minerals for therapeutic purposes have raised many concerns in the scientific committee since decades. Aim: To evaluate acute and subacute toxicity of Baladi Mandura in wistar albino rats. Materials and methods: acute oral toxicity study was carried out on wistar albino rats as per OECD 425 guidelines and subacute toxicity was performed as per OECD 407 guidelines. Results: Biochemical parameters showed significant decrease in SGPT value and increase in creatinine value in TED×5 group which is suggestive of liver and kidney damage. Effect of Baladi Mandura on the food intake and faecal matter analysis shows effective deepana property which is dose dependent. Histopathology study showed there were mild degenerative changes in the liver, kidney and lungs in higher dose. No toxic changes in therapeutic dose and half dose. Conclusion: These changes were absolutely dose dependent, and safer in therapeutic dose. Higher dose and long-term consumption at safer quantity needs to be tend cautiously.

Keywords: Therapeutic dose; Subacute toxicity; Creatinine; SGPT.


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