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Abstract

A NOVEL STUDY ON RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF NETARSUDIL AND LATANOPROST IN API AND PHARMACEUTICAL DOSAGE FORM

Dr. K. Padmalatha, D. Vijaya Durga* and N. Jagadeeswari

Abstract

A simple, Accurate, precise method was developed for the simultaneous estimation of the Netarsudil and Latanoprost in Opthalmic solution dosage form. Chromatogram was run through Agilent C18 150 x 4.6 mm, 5. Mobile phase containing KH2PO4: Acetonitrile taken in the ratio 55:45 was pumped through column on a flow rate at 1.0ml/min. Buffer used in this method was Potassium dihydrogen phosphate. Temperature was maintained at 30°C. Optimized wavelength selected was 220nm. Retention time of Netarsudil and Latanoprost were found to be 2.189min and 2.860min. %RSD of the Netarsudil and Latanoprost were and found to be 0.8 and 1.1 respectively. %Recovery was obtained as 100.25% and 100.11% for Netarsudil and Latanoprost respectively. LOD, LOQ values obtained from regression equations of Netarsudil and Latanoprost were 0.24, 0.09 and 0.72, 0.26 respectively. Regression equation of Netarsudil is y = 26436x + 3132.7. and y = 39041x + 2230.6 of Latanoprost. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Latanoprost, Netarsudil, RP-HPLC.


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