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Abstract

FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES OF NAPROXEN

Kiran Satnami*, Divya Prakash Jain, Nishi Prakash Jain and RB Goswami

Abstract

Rheumatoid arthritis can lead to severe disability in most counties worldwide including India. Naproxen is a NSAIDs used to treat various type of Arthritis. Solid lipid nanoparticles are immerged as versatile nano-sized drug carriers in this study we have prepared nontoxic, bio-compatible and easy to produced of Naproxen SLNs, Naproxen SLNs were prepared by High shear hot Homogenization technique at 65ºC temperature and 5000 rpm for 2 hrs. the globule size of Naproxen SLNs were reduced with help of probe ultra-sonicator for 10 minutes. Glyceryl Mono Stearate (GMS) was taken as a solid lipid while Tween 80 and Span80 were taken as surfactants. Various ratio between GMS with surfactants (Span80, tween80) were prepared and evaluated in term of particle size, percentage yield, Percentage entrapment efficiency (%EE) and Zeta potential. Batches Nap-SLN2,Nap-SLN3 and Nap-SLN4 were selected on the basis of above mention evaluation parameters. The particle size of these batches varies from 545nm- 682nm while % EE varies from 59 to 68%. The drug release studies of all three selected batches were performed using Franz diffusion cell for 24hrs. Batch Nap- SLN3 was optimized on the basis of linearity in different mathematical models, first order (R2 = 0.954), Higuchi model (R2= 0.897), Korsemeyer and Peppa‟s (R2= 0.998). Scanning electron microscopy (SEM) of optimized batch reveals it size and spherical shape, the prepared Naproxen SLNs can provide improved and reduced in viability of GI absorption of lipophilic and poorly water soluble Naproxen.

Keywords: Naproxen, Solid lipid nanoparticle, GMS, Arthritis, Probe ultra -sonication.


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