WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :

Download Article: Click Here

Search

Track Your Article

Abstract

STABILITY INDICATING RP- HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF CEFIXIME AND OFLOXACIN FROM PHARMACEUTICAL DOSAGE FORMULATION

Pralhad Rege*, Avinash Jagdale and Amol Kulkarni

Abstract

In present study, a successful attempt has been made to develop a simple, sensitive and validated RP-HPLC method for the simultaneous determination of Cefixime and Ofloxacin from combined pharmaceutical drug formulation. Chromatographic separation of Cefixime and Ofloxacin was achieved with gradient elution on C-18 column with mobile phase A- 0.1% formic acid in Water and mobile phase B- 0.1% formic acid in Methanol at a wavelength 250 nm. The method was validated in the terms of its linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Linearity of the method was found to be in the concentration range of 5-200 μg/mL for Cefixime and 5-200 μg/mL for Ofloxacin with correlation coefficient greater than 0.999 for both the analytes. The total eluting time for the both components is less than seven minutes. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of Cefixime and Ofloxacin in combined pharmaceutical drug formulations.

Keywords: RP-HPLC, Cefixime, Ofloxacin, Pharmaceutical drug formulations and Validation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More