Abstract

INVESTIGATION OF THERAPEUTIC ACTIVITY OF VITEX NEGUNDO NOCHI

Jeyavel Pandian R.*, P. Selvam and Vivek

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Abstract

Phytochemicals are ecologically derived plant secondary metabolites produced by the plants to protect them against environmental stress and invasions against pathogenic microbes. These phyto ingredients are known to elicit beneficial as well as pharmacological actions against human ailments. It is an established fact that the active principles present in the medicinal plants act synergistically to alleviate the primary and secondary complications of several diseases. Vitex negundo L. (Verbenaceae) is widely used as a therapeutic agent as well as dietary supplement for the treatment of Covid-19. In the present study, the ability of the aqueous extract VN in scavenging free radicals was assessed by using DPPH, ABTS, NO, FRAP and super oxide dismutase assays, in vitro anti-inflammatory activity by protein denaturation assay and antidiabetic activity against alpha amylase. VN also investigated for antibacterial activity against S.aureus and P.aeruginosa and Brine shrimp lethality test. The results obtained evidenced that the aqueous extract(VN-A) ethanolic extract(VN ET) possesses significant antioxidant and anti-inflammatory activity properties, moderate anti- diabetic activity the data presented provide scientific evidence for the antioxidant and other therapeutic efficacy of the medicinal plant, which in turn may be due to the presence of biologically active molecules present in the herbal.

Keywords: Vitex negundo, in vitro antioxidant assays, Anti-inflammatory, antidiabetic.