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Abstract

DEVELOPMENT AND VALIDATION OF UV - SPECTROMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ASPIRIN, ATORVASTATIN AND THEOPHYLLINE

Dinesh Vasu*

Abstract

The main objective of present research work was to develop and validate the UV- spectrophotometric methods for the simultaneous estimation of Aspirin, Atorvastatin and Theophylline pure drug form is based on simultaneous equation analysis by using methanol as a solvent. The simultaneous equation method depends on mainly that among three components (Aspirin, Atorvastatin and Theophylline) each of which absorbs at the λmax of each other, Results: The λmax of Aspirin, Atorvastatin and Theophylline was found to be 271nm, 246nm and 270nm respectively the linearity range of Aspirin, Atorvastatin and Theophylline between 4-20μg/ml, 8- 24μg/ml and 4- 20μg/ml respectively with correlation coefficient 0.9997, 0.9991, 0.9938 respectively. The system precision for Aspirin, Atorvastatin and Theophylline was found to be 0.018, 0.042 and 0.029. In all the cases values were within the acceptance limit of less than 2%. The mean percent recovery for Aspirin, Atorvastatin and Theophylline were found to be 100.2, 100.5, and 100.4 respectively. The method was validated for various parameters as per ICH guidelines and the results are found to be in acceptable limits.

Keywords: UV, Aspirin, Atorvastatin, Theophylline, Simultaneous Equation Method.


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