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Abstract

FORMULATION AND EVALUATION OF ANTIFUNGAL MICROEMULSION BASED GEL FOR TOPICAL DRUG DELIVERY USING MILLETIA PINNATA

Bhagyashri Gadave*, Atish Velhal and Dr. Vivekkumar Redasani

Abstract

The goal of this study was to develop and test a topical gel containing an Itraconazole microemulsion (ITZ). A preformulation research was conducted before the formulation of Itraconazole microemulsion. To determine the maximal solubility of ITZ in oils, surfactants and cosurfactants were tested to determine excipient potential. In order to microemulsion region, with Karanj oil as the oil phase, Tween 80 as the surfactant, and Isopropyl alcohol (IPA) as the co-surfactant, a pseudoternary phase diagram was created. The optimized ME of ITZ was characterized by its qualitative & Quantitative test & incorporated into polymeric gels of Carbopol (CBP), Xanthan gum, Carbopol 934, Carboxymethyl cellulose (CMC), Carboxymethyl -Tamrind gum (CMTG). ME evaluated by % transmittance, Viscosity, pH, particle size, zeta potential, Physical appearance, Drug content, pH, spreadability, viscosity, In -vitro release. Stable ME was obtained when Karanj oil was taken as oil phase, Tween 80 as surfactant & IPA as co-surfactant at the weight ratio of 5:45:50. The optimized ME based gel shows pH range 6.0- 6.34, Spreadability in the range of 0.56-1.06gm.cm/sec. The viscosity study indicated pseudoplastic behavior of all ME based gel formulations. Amongst the studied ME gels CBP: CMTG containing gels showed maximum drug release at the end of 6h. The prepared MEG show better release profile than marketed preparation.

Keywords: Itraconazole, Microemulsion based gel, Pseudoternary Phase Diagram, Topical drug delivery.


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