Abstract

AN OVERVIEW OF BIOLOGICAL ACTIVITIES OF THIADIAZOLE DERIVATIVES

Rakesh Singh*,Dr. Anuja Chouhan

Abstract

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Several five membered heterocyclic compounds having three hetero atoms such as thiadiazoles, oxadiazoles etc have been studied extensively owing to their interesting pharmacological activities. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behaviour have gained more importance in recent decades Various substituted thiadiazole compounds are associated with diverse pharmacological activities such as anti-microbial, anti-inflammatory, anti-tubercular, anti-fungal, anti-malarial, anti-diabetic, diuretics, antidepressant, anticonvulsant, antioxidant, anti-leishmanial, antidiabetic, antiviral activities. The present review highlights the recently synthesized thiadiazole derivatives possessing important biological activities.

Keywords: 1, 3, 4-Thiadiazole, antimicrobial, anti-tubercular, antifungal, antiinflammatory and anticancer activities.