Abstract

HBA1C IS NOT SUFFICIENT GLUCOSE CONTROL ASSESSMENT TOOL IN TYPE 1 AND TYPE 2 TREATED WITH INSULIN DIABETES PATIENTS

Tzvetelina Tzvetanova Totomirova* and Mila Vasileva Arnaudova

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Abstract

HbA1c is currently used for assessment of glucose control in type 1 and type 2 diabetes patients treated with different therapeutic regiments. Its level is affected by different conditions besides glucose concentration and, in many cases, HbA1c is insufficient to present glucose control. In our study we compare representativeness of usually used control assessment tools such HbA1c and multiple daily blood glucose measurements with results derived from (CGM) continuous glucose monitoring records. We studied 75 diabetic patients (43 men, 32 women; age 55.23±8.99 years, disease duration 12.84±7.02 years) - 33 with type 2 diabetes on pre-mixed insulin, 21 with type 2 on multiple insulin injection (MII), 21 with type 1 on MMI. Patients performed multiple daily blood glucose measurements of fasting and prandial blood glucose for three month period. HbA1c was measured and CGM by using iProTM for seven days was performed at the end of this period In pre-mixed insulin treated group and type 2 with intensified regimen moderate positive correlation was found between HbA1c and mean blood glucose derived from CGM (7.64±1.40% and 7.69±1.23%, respectively 7.64±1.48mmol/l and 7.60±1.30mmol/l), with r1=0.642 (p

Keywords: HbA1c, Glucose control, Diabetes, Continuous glucose monitoring.