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Abstract

CORONAVIRUS [COVID -19] -A SCOPING REVIEW

Abhijeet Karkhile*, Punam Kamble, Adesh Thube, Ashwini Andhale, Santosh Wghmare and Hemant Kamble

Abstract

The 2019 Novel Corona virus infection (COVID 19) is an ongoing public health emergency of international significance. The novel COVID-19 coronavirus Initially observed in the Wuhan province of Following reports of patients with unexplained pneumonia at the end of December 2019 in Wuhan, China, now fatly spreading around the world. There are significant knowledge gaps in the epidemiology, transmission dynamics, investigation tools and management. In this article, we review the available evidence about this disease. As this pandemic is very new and very less scientific material is available on the topic. The causative agent was identified as coronavirus (SARSCoV- 2), and the 2019 novel coronavirus disease was named COVID 19 by the World Health Organization. the severe acute respiratory syndrome coronavirus (SARS-CoV-2) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-Cove, COVID-19 virus exploits the angiotensin converting enzyme 2 (ACE2) receptor to gain entry inside the cells. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host−virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. it is important to consider potential plausible mechanisms by which hypertension or hypertension medications might influence COVID-19 severity. The mechanisms underlying the purported association between COVID-19 severity and hypertension are not clear, but some evidence points towards a pathogenic role for the renin–angiotensin system (RAS), as it is tied directly to both viral transmission and hypertension.

Keywords: Immune system against Covid-19, Genetic Recombination in Coronaviruses, Epidemiology and Pathogenesis, Virus isolation, Collection of specimens for laboratory diagnosis, RT-PCR.


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