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Abstract

A SYSTEMIC REVIEW ON: OPHTHALMIC DRUG DELIVERY SYSTEM AND ITS FUTURE PERSPECTIVE CHALLENGES

Roshan Kumar Dubey*, Bhupendra Kumar Kumawat, Vivek Kumar Patel, Vedant Kumar Prajapati and Ganesh Lal

Abstract

Ocular drug delivery has always been a challenge for ophthalmologists and drug delivery scientists due to presence of various anatomical and physiological barriers. Inimitable static and dynamic ocular barriers not only exclude the entry of xenobiotics but also discourage the active absorption of therapeutic agents. Designing an ideal delivery scheme should include enhanced drug bioavailability and controlled release of drug at site of action which can overcome various ocular barriers. Conventional ophthalmic medications includes; the use of topical eye drops and intravitreal injections of anti-VEGF agent for treatment of anterior and posterior segment disorders, respectively. Current inventions for anterior ocular segment disorders like punctum plugs, ocular implants, drug eluting contact lenses, and ocular iontophoresis represent state of the art inventions for sustained and controlled drug release. The tool of nanotechnology provides several essential advantages, including sustained drug release and specific tissue targeting. The development of lipid-based nanocarriers has emerged into pharmaceutical industries and attracted attention from formulation scientists for its high drug solubility, substance release, and specific targeting. Organic nanoparticles, such as liposomes, polymeric nanoparticles, and dendrimers, are fabricated and developed to improve therapeutic drug delivery for the ocular disease. Inorganic nanoparticles have garnered significant attention for their theranostic properties, substance release, and specific targeting. In this review, we aim to provide an insight into current treatment modalities based on nanotechnology for drug delivery in the eye.

Keywords: Nanoparticles, Nanomicelles, Dendrimers, Organic and inorganic nanoparticles.


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