Abstract

GEL FORMING OCCLUSIVE FILM FOR TOPICAL AND TRANSDERMAL DRUG DELIVERY SYSTEM

Manisha R. Chavhan*, Ashvini Y. Parbat, Farheen A. Shah, Sudhakar M. Jagtap, Manisha D. Kitukale and Anil V. Chandewar

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Abstract

Skin is considered as an important route of administration of drugs for both local and systemic effects. The polymeric solution is applied to the skin as a liquid and forms an alomost invisible film in situ by solvent evaporation. Transdermal drug delivery system and dermal drug delivery system can provide some desirable performance over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing drug delivery profile. The aim of this review was to search for alternative to conventional forms in order to reduce skin irritation, improve skin adhesion properties, enhance the drug release and increase the patient acceptability from an aesthetic perspective. The polymeric gels are beneficial in terms of ease of preparation, ease of application, produce site specific drug delivery for local and systemic effect, increase the duration of drug action.

Keywords: Film forming polymers, Topical drug delivery, Gelling agents.