Abstract

A BRIEF REVIEW: NASAL THERMOREVERSIBLE IN SITU GEL LOADED WITH ANTI-DIABETIC DRUG AND NATURAL ANTIOXIDANT TO TREAT DIABETES-INDUCED ALZ HEIMER DISEASE

Anuja Anku* and Dr. Konde Abbulu

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Abstract

The present review was focused on study of Nasal thermoreversible In situ gel which contains the combination of antidiabetic agent with natural antioxidant to manage diabetes-induced Alzheimer disease in elderly population with Type-2 diabetes. The in situ gelling systems for nasal administration were developed to improve patient compliance, nasal bioavailability of drugs by increasing its nasal retention time and for improvement of drug safety and efficacy in our body system. Antidiabetic drug which is used is Metformin, a biguanide antihyperglycemic agent used for the treatment of type-2 diabetes is well known for its major role as neuroprotective by decreasing the insulin receptor phosphorylation and tauphosphorylation and increasing neuronal survival. Curcumin has been reported to inhibit amyloid-β-protein (Aβ) aggregation, and Aβ-induced inflammation, as well as the activities of β-secretase and acetylcholinesterase and has resulted in the inhibition of Aβ deposition, Aβ oligomerization, and tau phosphorylation in the brains of AD patients. The present review also focused on the formulation of in situ gelling system with respect to physiological temperature and the study of various other approaches. The different kind of polymers used and their role in preparation of gelling system and absorption of drugs by various ways are also discussed in this review. Various evaluation parameters also considered in preparation of nasal in situ gels.

Keywords: Metformin, Curcumin, Diabetes-induced Alzheimer’s, Thermoreversible polymers, Approaches.