Abstract

PREPARATION AND TESTING OF AMPICILLIN-BASED IONIC LIQUIDS

Ratna Singh*, Swarnim Srivastava and Ganesh Lal

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Abstract

To overcome the problems associated with low water solubility, hence the low availability of active pharmaceutical ingredients (APIs), here we find a modular liquid formulation for advanced APIs. Ionic drinks containing ampicillin as an active medicinal ingredient in the anion were designed using a modified method in our previous work, the use of natural cations was determined by salts substituted for ammonium, phosphonium, pyridinium, and methylimidazolium salt, due to improved melting and availability of ampicillin forms. To test the key properties of the combined API-IL, water melting at 25 ⁰C and 37 ⁰C (body temperature) as well as octanol-water partition coefficients' (Ko / w's) and HDPC micelles partition 25 ⁰C rated. The concentration of micelle critical (CMC's) in water at 25 ⁰C and 37 ⁰C for ionic acid beverages has been further determined from ionic conductivity measurements.

Keywords: Active medicinal ingredients, ionic beverages, soluble, soluble, Octanol - water partition coefficients’, Critical micelle concentrations.