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Abstract

SDC-PC BASED SOLID SEDDS OF BCS CLASS III DRUG

Aneri V. Adsul*, Bharatee P. Chaudhari and Vivekkumar K. Redasani

Abstract

Aim: The purpose of this research is to develop, optimise, and analyse losartan potassium loaded solid SEDDS using a newly synthesised surfactant. Losartan potassium is an angiotensin II receptor blocker that belongs to the BCS class III of antihypertensive drugs. Solid SEDDS were used to increase the permeability, oral bioavailability, and first pass metabolism of losartan potassium, which had a low permeability and oral bioavailability. Material and methods: As a surfactant, SDC-PC was synthesized. The solubility of the API in various oils, surfactants, and co-surfactants was investigated, and oleic was chosen as the oil phase, SDC-PC as the surfactant, and PEG 400 as a co-surfactant for formulation. A pseudo-ternary phase diagram was created to get the ideal emulsification area. SEDDS liquid was prepared and tested. Following an evaluation, it was discovered that LP4 was stable and optimum. Result and discussion: Aerosil 200 was used as a carrier to convert the formulation into solid SEDDS. The formulations were compared to LOSARĀ®, as marketed product. On in-vitro drug release, optimised batch LP4 was shown to have similar drug release to the marketed formulation.

Keywords: Losartan potassium, SEDDS, Surfactant, Solid dosage form, Pseudo-ternary phase diagram.


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