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Abstract

FORMULATION AND EVALUATION OF RIZATRIPTAN FAST DISSOLVING TABLETS UTILIZING DIFFERENT SUPER DISINTEGRANTS WITH SPECIAL EMPHASIS ON FENUGREEK

Satyanand Mourya, Ganesh Lal*, Roshan Kumar Dubey and Vivek Kumar Patel

Abstract

Introduction: FDTs (Fast Dissolving Tablets) are intended to dissolve quickly, allowing for excellent oral delivery without the need of water. Chewing these formulations also provides improved convenience and simplicity of administration, as well as a substantial potential effectiveness in improving patient compliance, particularly in populations that have difficulty swallowing traditional solid oral dose forms. Materials and Methods: Rizatriptan was used as API and different super disintegrants were used. Fenugreek was one of the super disintegrant. Pre formulation studies were performed on the raw materials. Different formulations were prepared using different technique and they were evaluated for various parameters. Results: The purpose of this study was to find the best combination of super disintegrants for the creation of Rizatriptan benzoate orally disintegrating tablets. Ten formulations were prepared with different super disintegrants. Formulation F8 containing fenugreek as super disintegrant was found to be more efficacious as compared to other formulations. Conclusion: Croscarmellose sodium, sodium starch glycolate, and Cross-povidone were used as super disintegrants. A total of ten formulations were produced using the direct compression technique & assessed for friability, in-vitro dispersion time, hardness, wetting time, and water absorption ratio. The highest percentage drug release was determined to be 99.80 in formulation FD8.

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