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Abstract

SYNTHESIS AND EVALUATION OF CYTOTOXIC ACTIVITY OF SOME ISATIN DERIVATIVES

Sachin Laxman Munde*, Syeda Farheen Fatema, Dhotre Bhagyashree Gopalrao, Mirza Nazish Baig, Priya Shivaji Shep and Shivaji Solunke

Abstract

Isatin nucleus was found to possess many pharmacological activities like anti-inflammatory, antihistaminic, antiviral, anticancer, anticonvulsant, antioxidant etc. Hence attempts were made to synthesize isatin analogues with cytotoxic activity. Purity of the compounds were determined by TLC and melting point. Formation of all the derivatives were confirmed by FT-IR, 1HNMR, Mass spectrum. In vitro cytotoxic effect of synthesized compounds IVa-d was evaluated on the growth of allium cepa root meristems and the effect was compared with standard cytotoxic drug cyclophosphamide. Compound IVa-d possesses poor to good cytotoxic activity at the concentration of 10 mg/mL. All the compounds are almost ineffective at 1 mg/mL concentration. Cytotoxic activity exhibited by cyclophosphamide is very significant as compared to all the derivatives at both the concentrations.

Keywords: Isatin, FTIR, cytotoxic activity, cyclophosphamide.


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