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Abstract

FORMULATION AND EVALUTION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIPIZIDE

Swati S. Rawat* and Falguniben I. Rohit

Abstract

The oral route is the most popular route due to ease of administration and to the fact that gastrointestinal physiology offers more flexibility. The matrix system is one of the intricate approaches for the preparation of the sustained release dosage forms and formulation of matrix tablet has gained immense popularity now a day because it has the advantage of simple processing and low cost of fabrication. Formulated oral sustained release matrix tablets of Glipizide in order to improve efficacy, reduce the frequency of administration, and better patient compliance. In present investigation an attempt has been made to design and develop Glipizide matrix tablets using combination of hydroxy propyl methyl cellulose K 100 MCR and hydroxy propyl methyl cellulose K4M as release retarding polymers. Glipizide is an oral hypoglycaemic drug which lowers blood glucose level and has been selected to prepare sustained release dosage forms. The prepared granules were evaluated for various flowability parameter the Husner ratio was found in the range 1.16±0.007 to 1.20±0.01, compressibility index were found to be in the range 21.71±4.47 to 26.41±0.38, and angle of repose were in the range in respectively 22.69±0.81 to 29.56±0.55 in the formulate F1 to F9 respectively. The weights of the tablets were in the range of 200±8 mg. The thickness of the tablet was in the range of 3.62±0.01 to 3.66±0.06 mm. As the time increases, the swelling index was increased; later on it decrease gradually due to dissolution of outermost- gelled layer of tablet into dissolution medium. Drug content uniformity study showed uniform dispersion of the drug throughout the formulation in the range of 96.8±0.99 99.9±0.57%. The maximum drug release was found to be 99.35 % over a period of 24 hours. Stability studies reveled that there were no significant changes in physical properties and drug content of formulation F8 the selected formulation was stable. It can be concluded that combination of HPMC K100MCR and HPMC K4M can be used as an effective matrix former to sustained the release of Glipizide for an extended period of 24 hrs.

Keywords: Hypoglycaemic, Blood glucose level, Glipizide, Sustained release, Matrix tablets.


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