WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :

Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-PHENYL THIOSEMICARBAZIDE DERIVATIVES AS ANTIINFLAMMATORY AGENT

Ayush Singh*, Navjot Singh and Shweta Singh

Abstract

Thiosemicarbazides derivatives were synthesized by reacting 5-chloro- 2-hydrazinylbenzo [d]oxazole and substituted phenyl isothiocyanate then characterized for Molecular formula, Physical state, Color, Melting point, Yield, Solubility and Rf – value. Structure of synthesized Thiosemicarbazides derivatives were elucidated using spectrogram data as well as physical method e.g. Elemental analysis, FT-IR, 1H NMR and mass. Moreover, synthesized compounds characterized by the TLC and melting point. In addition, by visual inspection synthesized compounds also characterized. Novel synthesized Thiosemicarbazides derivatives were evaluated in- vitro for anti-inflammatory activity by kit available in market estimate the inhibition of Cox-1 and Cox-2 activity. Novel synthesized Thiosemicarbazides derivatives TSCZ-5 was exhibited excellent antiinflammatory activity against COX-1 & Cox-2 with IC50 value less than

Keywords: 4-phenyl Thiosemicarbazides, anti-inflammatory, Cox-1 and Cox-2.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More