Abstract

IMPACT OF SURFACTANT TO CHOLESTEROL RATIO ON THE CHARACTERISTICS OF ZIDOVUDINE NIOSOMES

T. Srinivas*, Sundararajan G., S. Manohar Babu and Chalapathi R.

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Abstract

The aim of the present work was to develop Niosomes drug delivery system with zidovudine as model drug. The surfactant selected was Span 60 and lipid forming agent was cholesterol. It was planned to have 6 formulations falling into two categories based on the method of preparation namely Ether injection method and Film hydration method. Under each category, 3 formulations were designed containing different span 60: cholesterol ratio. Formulation E1, E2 and E3 contain span 60: Cholesterol ratio of 1:1, 2:1, 3:1 respectively and prepared by Ether injection method. Similarly, formulations F1, F2 & F3 contain span 60: cholesterol in the ratio of 1:1, 2:1, 3:1 and prepared by film by hydration technique. The prepared formulations were evaluated. It was found that the Entrapment efficiency of the Niosomes increased on increasing the amount of span 60. The trend was demonstrated in both categories of Niosomes prepared by ether injection & film hydration technique. The invitro drug release studies were done for 12 hours. The characteristics of the formulations were compared and found that the drug release was increase in the formulation containing more amount of surfactant. The formulation with 1:1ratio of span:cholesterol showed slow release of drug when compared to other formulations containing high amount of surfactant.

Keywords: Niosomes, Ether injection Method and Film hydration method.