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Abstract

DEVELOPMENT AND EVALUATION OF FAST DISSOLVING AMLODIPINE BESYLATE TABLETS

Surabhi Sinha and Vedant Kumar Prajapati*

Abstract

Fast dissolving drug dosage form is a better way for the treatment of paediatric, geriatric, nauseous, bedridden and noncompliant patients. It is also better for those who have difficulty in swallowing the solid unit dosage form and best suitable for those patients also who have fear of chocking due to tablet engulfing. Amlodipine Besylate is the besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Mouth dissolving tablet of Amlodipne besylate is formulated by two method i.e. direct compression and sublimation method. Amlodipne besylate is identified with the help of FTIR And standardization through UV/VIS spectroscopy. Drug excipient compatibility is checked by the IR spectral analysis of formulations. The blended powder is then inspected for micromeritic properties like bulk density, tapped density, compressibility index, hausner ratio and angle of repose. The value obtained is within the prescribed limit and show good flow properties. When blended powder is compressed into tablets then these tabets are evaluated for post compression parameter. The amalgamation of superdisintegrant (cross povidone) and subliming agent (camphor) is best shown in the formulation SX6 and SX9 in ratio of 20:15 and 20:20. In the sublimation method the in-vitro dispersion and in-vitro disintegration time is good. About 99.80% drug was released within 6 sec by sublimation method. In drug kinetics the Peppas and Korsmeyer kinetics ispassed.

Keywords: Fast dissolving, Amlodipne besylate.


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