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Abstract

A REVIEW ON ATOVAQUONE AND BUPARVAQUONE PRODRUGS

Sanjay S. S.*, Shridhara K. and Shashiprabha

Abstract

Naphthoquinone ring forms a prominent structural feature in many pharmaceutical compounds having therapeutic efficacy for various pathogens. Both Atovaquone and Buparvaquone drugs belong to this class, these drugs were predominantly used for treating malaria and protozoal infections. Both the parent drug molecules have very low bioavailability due to poor solubility, contributing to the need of inducing high dose during the treatment. Various studies have been carried out to overcome these issues, with a considerable focus on reducing the particle size or to introduce the novel prodrugs of these molecules. Noticeable work has been done to reduce the particle size, whereas very less volume of published literature is available on the prodrugs of these two under-focus drug molecules. In this review, efforts were put in to compile the available literature towards the progressive disclosures on the synthesis and the therapeutic advantages of Atovaquone and Buparvaquone prodrugs.

Keywords: Atovaquone, Buparvaquone, Prodrugs, Solubility, Bioavailability, Drug efficacy.


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