Abstract

PILOT STUDY ON POLYHERBAL EXTRACT FOR ANTIDIABETIC ACTIVITY IN ALLOXAN - DIABETIC RATS

*Chaitanya Sravanthi Kota, Dr. Hemanh kumar V, Dr.Hemalatha E

Abstract

The metabolic disorder which has become more common in world population is Diabetes mellitus. A number of medicines are available but still this disorder search for a drug with fewer side effects. This gained interest for complementary therapies. In this regard, a pilot study on methanol polyherbal extract (AChCaT is Acacia, Chloroxylon, Casearia, Terminalia extract) extracted from Acacia ferruginia (bark & fruit), Chloroxylon swietenia (bark, leaf, root), Casearia elliptica (bark), Terminalia alata (root, leaf) was evaluated for antidiabetic activity in Alloxan induced diabetic rats. Rats of body weight 180-200gms were administered with alloxan dose 120mg/kg body weight to induce diabetes. Animals are grouped as Group I (Normal rats), Group II (Diabetic control - Alloxan treated), Group III (Diabetic+ Glibenclamide (10mg/kg)), Group IV (Diabetic + Polyherbal extract). The polyherbal extract were administered with dose of 400mg/kg using CMC solution (5%) as the vehicle. Blood glucose in Group I, II, III, IV on 14th day are 108±1.14, 369.4 ±10.25, 161.6 ±3.41, 170.4 ±2.13 respectively .Data shows that Group IV is near to standard in giving hypoglycemic effect. Body weights of Group I, II, III and IV on 14th day are 187.2±0.96, 165.8±1.2, 179±0.77, 184.6±0.67 and no toxic effects were observed in the Test Group (Group IV). Body weights and blood glucose levels were compared with Group II

Keywords: Antidiabetic activity, Acacia ferruginia, Chloroxylon swietenia, Casearia elliptica, Terminalia alata, Poly herbal extract, Alloxan.