Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERE OF CEFUROXIME AXETIL

Mahesh Gour*, Rahul Sharma and Dr. Jagdish Chandra Rathi

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Abstract

The present study involves preparation and evaluation of floating microspheres using Cefuroxime axetil as a model drug for improving the drug bioavailability by prolongation of gastric retention time. Ethyl cellulose, hydroxyl propyl methyl cellulose microspheres loaded with Cefuroxime axetil were prepared by solvent diffusion evaporation method. The microspheres had smooth surfaces with free-flowing and good-packing properties. Percentage yield of different formulation was determined by weighing the Microspheres after drying. The percentage yield of different formulation was in range of 62.23±0.85– 73.32±0.65%. The maximum Percentage yield was found in formulation F3, 73.32±0.65 as compare to all formulation tables 2. The drug entrapment efficacies of different formulations were in range of 63.23±0.65- 76.56±0.65% w/w table 3. The maximum percentage yield, drug entrapment, percentage buoyancy and floating lag time was found to be formulation F3 in floating microsphere. When the regression coefficient values were compared, it was observed that an ‘r2’ value of microsphere was maximum zero order i.e 0.958 hence indicating drug releases from formulations was found to follow zero order for floating microsphere. It was concluded that developed floating microspheres of Cefuroxime axetil offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.

Keywords: Cefuroxime axetil, Solvent diffusion evaporation method, Ethyl cellulose, Hydroxyl propyl methyl cellulose.