Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG LANSOPRAZOLE

Keval Khatik*, Rahul Sharma and Dr. Jagdish Chandra Rathi

.

Abstract

Lansoprazole (LSZ) is a substituted benzimidazole and selectively inhibits the H+/K+-ATPase of the parietal cell of the stomach. As a representative proton pump inhibitor, LSP has been clinically used in the therapy of gastric and duodenal ulcerative disease with a superior or equivalent clinical efficacy to H2 receptor antagonist. However, the bioavailability of LSP was not consistent with wide intersubject variation, which is ascribed to the variation in the genotype of CYP2C19, possible degradation by the gastric acid, and limited water solubility Low aqueous solubility is a major problem faced during formulation development of new drug molecules. Lansoprazole (LPZ) is an anti ulcer agent and is a good example of the problems associated with low aqueous solubility. Lansoprazole is practically insoluble in water. Hence, purpose of this research was to enhance the solubility of Lansoprazole by using the concept of solid dispersion. The present investigations showed that solubility of Lansoprazole was markedly increased by its solid dispersion using PVP K30 as carrier. The formulation SDF8 containing (1:4) shows highest dissolution rate. Hence the solid dispersion a way is useful technique in providing fastest onset of action of Lansoprazole as well as enhanced dissolution rate.

Keywords: Lansoprazole, Solubility enhancement, Solid dispersion, PVP K30.