Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF BENZOXAZOLE SUBSTITUTED AZETIDINONE DERIVATIVES AS ANTICANCER AGENTS

Leyana P. N.*, Manju P. T. and Meenu Vijayan

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Abstract

Benzoxazole is a heteroaromatic compound, which finds use in research as a starting material for the synthesis of biologically active structures. Azetidinone is a potent, orally active beta lactam which exhibit a number of biological activities like anti-cancer, anti-viral and anti- inflammatory. Among all the heterocycles, benzoxazole and azetidinone are the most important heterocycles exhibiting remarkable anticancer activities. A series of Benzoxazole substituted azetidinone derivatives were synthesized, characterized and evaluated for the anticancer study. The structures were confirmed by 1H NMR, 13C NMR and MASS spectral techniques. The docking study of synthesized compounds were done to find the binding activity of the derivatives to the VEGFR-2 receptors.

Keywords: Benzoxazole, Azetidinone, Anticancer activity.