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Abstract

FORMULATION AND EVALUATION OF INVASOMES OF TAZAROTENE FOR POTENT ANTI ACNE EFFECT

Falguni Deoghoria*, Dr. Jagdish Chandra Rathi and Rahul Sharma

Abstract

Tazarotene- loaded invasomes were prepared and evaluated for average vesicle size, zeta potential and entrapment efficiency. The effect of varying concentration of phosphatidylcholine on average vesicle size was studied. The Average vesicle size was found to be in the range of 220.14 ± 0.25 to 345.58 ± 0.41. Drug entrapment efficiency of Invasomes formulations is reduced with lowering concentration of lacithin. In general charged invasomes were more stable against aggregation and fusion than uncharged invasomes. The optimized formulation of invasomes was further incorporated into Carbopol gel base and evaluated for viscosity, pH, Spreadability and in-vitro drug release. The pH of the Gel was found to be in range of 6.75 ± 0.02 to 6.98 ± 0.02 which is good for skin pH. Drug content of tazarotene incorporated invasomes gel for formulation IG-1, IG-2 and IG-3 was found to be 96.65 ± 0.15, 99.12 ± 0.25 and 98.58 ± 0.32 respectively. In conclusion, the invasomes delivery systems may be a promising carrier for transdermal delivery of tazarotene for the management of treatment of acne.

Keywords: Tazarotene, invasomes, transdermal, acne, lecithin.


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