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Abstract

TOXICITY STUDIES OF YOYO CLEANSER BITTERS POLYHERBAL FORMULATION IN ALBINO RATS

Timipa R. Ogoun, Odangowei I. Ogidi* and Thomas Aye

Abstract

There is a resurgence of interest in the use of herbal supplements in developing countries arising from the unsubstantiated belief of the safety of the supplements. The toxicity of a popular Nigerian polyherbal preparation (Yoyo cleanser bitters) on biochemical functions of the liver and kidney of albino rats was investigated. Twenty (20) adult albino rats were used for this research. Yoyo cleanser bitters treated groups (n=5) was administered to each rat at 5, 10 and 15 mg/kg body weight. Treatment of the animals was done for 14 days after the 7 days acclimatization before sacrificing them through cervical dislocation. Blood was collected by cardiac puncture, using 5ml syringes and 23G needles into blood sample containers for biochemical analysis using the standard principles of biochemical analysis. The result of the study shows minimal and non- significant increase of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), albumin, creatinine, total bilirubin and total protein of the herbal formulation when compared with the control. However, there was a significant increase in serum levels of urea (10 and 15 mg/kg doses) and total cholesterol (TC) (5 and 10 mg/kg doses) on the treated groups. It can therefore be concluded that the poly-herbal formulation at the used doses and duration of the study on AST, ALP, ALP, albumin, creatinine, total bilirubin and protein might not cause any form of cholestasis and may not impair the capacity of the liver to excrete bilirubin. They might not also have a reno-toxic effect on the kidneys due to the reduced levels of creatinine. But on some increased values of urea and TC which might lead to reduced renal function and hepatobiliary disorder and impaired cholesterol metabolism and as such a call for caution on the use of the poly-herbal formulation on higher therapeutic doses and longer duration of time.

Keywords: Yoyo cleanser bitters; Toxicity; Liver; Kidney; Biochemical parameter; Albino rats.


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