Abstract

A POSSIBLE AMELIORATIVE ROLE OF CURCUMIN IN DECLINING THE SIDE EFFECT OF METHOTREXATE IN ADJUVANT INDUCED ARTHRITIS

Mohamed Hazem Al-Doori, Marwa T. Hassen* and Sahar S. Abd-Elhalem

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Abstract

Our study aimed to identify the role of curcumin in overcoming the toxicity of methotrexate on liver in adjuvant-induced arthritis. Rats were divided into eight groups. (Control), without treatment. (MTX), was injected (IP) with methotrexate in a dose of 0.75 mg/kg b.w./week for 20 days. (CUR), was treated with a daily oral dose of curcumin (150 mg/kg b.w./day) for 20 days. (MTX + CUR), was treated with methotrexate and curcumin as the same previous corresponding dose and period. (AA), was injected with Complete Freund’s adjuvant for arthritis induction. (AA/MTX), arthritis induction then treated with methotrexate as the same previous dose and period. (AA/CUR), arthritis induction then treated with curcumin as the same previous dose and period. (AA/MTX +CUR), arthritis induction then treated with both methotrexate and curcumin as the same previous dose and period. Results showed significant improvement in body weight, liver weights, WBCS count, RBCS count, and HB level in rats treated with either MTX alone or with CUR. The combination of MTX + CUR revealed notable activities in a decreased ANA level. Generally, MTX + CUR administration exerted restorative effects on the liver structure and functional damages.

Keywords: Arthritis, Methotrexate, Curcumin.