Abstract

RECENT ADVANCES IN THE SYNTHESIS AND MEDICINAL APPLICATION OF HYDANTOIN: A VALUABLE SCAFFOLD IN MEDICINAL CHEMISTRY

Dr. Pratima Katiyar, Shivam Kumar Verma*, Sadhana Umar, Pramod Chauhan, Dr. Kalpana and Dr. Neeraj Verma

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Abstract

Imidazolidine-2,4-dione, or hydantoin, is a non-aromatic fivemembered heterocycle ring. In medicinal chemistry, this nucleus is regarded a valuable and privileged scaffold. Several drugs in clinical usage, such as phenytoin, nitrofurantoin, and enzalutamide, have underlined the value of the hydantoin scaffold in drug discovery. Two hydrogen bond acceptors and two hydrogen bond donors are among the five possible substituent sites in hydantoin. Because of its flexibility to accept a variety of substituents and synthetic feasibility for nucleus scaffolds by well-known cyclization procedures, the hydantoin moiety has been emereged as a attractive ring among the researchers. One of the oxidised forms of imidazolidine with a cyclic urea core form hydantoin ring is one such example. Hence As a result of these properties, a wide range of hydantoin derivatives with various substituents have been devised and synthesised. In this review, including the chemical properties of hydantoin ring its ring synthesis via various methods and its application in medicinal field. The previous letrature of hydantoin-containing compounds exhibit a wide range of pharmacological and biological activities, including anticancer, anti-inflammatory, anti-immune activity, activity against metabolic disease, antioxidant, antimicrobial, CNS- related activity, anticonvulsant, antitussive, and cytoprotective activity, activity against erectile dysfunction.

Keywords: Imidazolidine, Non aromatics, hydantoin, phenytoin, Urea, Drug discovery, Nitrophenytoin.